|
KMID : 0363319990200010143
|
|
Journal of Korean Oriental Internal Medicine
1999 Volume.20 No. 1 p.143 ~ p.152
|
|
|
Nitric Oxide Generation from Peritoneal Macrophages by Salvia miltiorrhiza Root Water Extract
|
|
Cho Hyun-Joo
Moon Seok-Jae
|
|
|
Abstract
|
|
|
|
Dansam, the root of Salvia miltiorrhiza Bge, (Labiatae), has a bitter taste and a slightly ’cold’ property, and is nontoxic. In the present study, effect of Dansam on nitric oxide (NO) generation from peritoneal macrophags was examined. Dansam had no effect on NO generation by itself, whereas recombinant interferon- alone had modest activity. When Dansam was used in combination with , there was a marked cooperative induction of NO generation in a dose-dependent manner, The optimal effect of Dansam on NO generation was shown at 6 hr after treatment with . Furthermore, the effect of Dansam was mainly dependent on Dansam-induced tumor necrosis secretion. These results suggest that Dansam induces NO generation from macrophages by the result of Dansam-induced secretion.
|
|
|
KEYWORD
|
|
|
Dansam, Nitric oxide, Peritoneal macrophages, Recombinant interferon-, Tumor necrosis factor-α
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|